Gabapentin, an anticonvulsant used for the treatment of epilepsy and neuropathic pain, is metabolized via CYP3A4. Using this enzyme, it can be transformed into gabapentinol or norgabapentinol through oxidation..It was initially approved in 1993 as Neurontin and then re-approved in 2005 as Gabapentin. It is used to treat nerve related pain, including shingles and diabetic neuropathy. It is also used to help control seizures in children who are at least 2 years old (for Lennox-Gastaut syndrome) or for certain types of postherpetic neuralgia or Bell’s palsy.
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